Nicotinamide adenine dinucleotide (NAD+) is an essential cofactor and substrate for a number of critical cellular processes.
NAD+ is an essential and natural substrate in the energy generation process, as well as many processes controlling aging.
NAD+ levels decline with aging, which can be attributed to a wide array of age-associated pathophysiologies.
NAD+ is part of the energy production process in Krebs cycle.
NAD+ exists in almost every cell of the body, participates in cell metabolism, provides energy, reduces the formation of free radicals and repairs DNA damage.
NAD+ in cardiovascular health: Cardiomyocytes are mainly powered by aerobic metabolism.Cardiomyocytes are rich in mitochondria, and a decrease in NAD+ levels can lead to excessive cardiac stress, such as myocardial infarction (MI) or ischemia reperfusion (IR) injury. Continued oxidative stress can cause the entire NAD+ to be depleted, eventually leading to mitochondrial dysfunction and cardiomyocyte death. Exercise, diet, and an effective NAD+ precursor restores NAD+ and mitochondrial function.
NAD+ and blood pressure: In mice with preeclampsia, nicotinamide, a potential precursor that supplements NAD+, was found to decrease blood pressure and endotheliosis in mothers. Recently, it was demonstrated that nicotinamide effectively decreased blood pressure in hypertensive mice because of the anti inflammatory effects]. Furthermore, another study showed that nicotinamide riboside, also a precursor of NAD+, can reduce systolic blood pressure and aortic stiffness.
NAD+ and cardiovascular disease: Increasing NAD+ through effective precursor supplements has not only shown efficacy in cardiovascular diseases in a variety of animal models but also shown satisfied outcomes for the prevention and treatment of CVDs in humans.
Aging results in changes to the structure and function of the vasculature. Sirtuins and NAD+ can improve or reverse some aspects of vascular aging (as marked) through modulation of targets.
Increasing NAD + levels isn’t just important but rather it is critical to optimize healthspan as well as optimizing clinical outcomes when dealing with the many forms of cardiovascular disease.
decreases LDL cholesterol levels
reduces vascular cell senescence (essentially anti-aging; it prevents growth arrest in the cell that is caused by oxidative stress/damage, inflammation and DNA damage)
increases NO (nitric oxide) through endothelial nitric oxide synthase (eNOS)
reduces inflammation through nuclear factor kappa-light-chain-enhancer of activated B cells (NFκB) modulation
decreases oxidative stress by modulating FOXOs and thrombosis via tissue factor (TF) and peroxisome proliferator-activated receptor delta (PPARδ)
increases angiogenesis through modulation of FOXO1 and NICD-Notch.
NAD+ can be used for the following: Energy support, chronic fatigue syndrome, anti-aging/longevity support, age-related diseases, alcohol/ opioid detoxification, neuro-degenerative disorders, PTSD, stress, fibromyalgia.
Due to a lack of documentation, the following patients and conditions are not recommended for the use of NAD+: Pediatric, Pregnancy, Lactation: Insufficient reliable data available

➢ Many people successfully heal from infection after a few rounds of ozone blood therapy in an integrative clinic ❖ Ozone gets a bad rap because smog is made up of ozone. Inhaling ground-level ozone/smog can irritate the lungs.

❖ Pure, medical grade ozone administered correctly by a licensed medical practitioner has the potential to make your body function at its highest level.

❖ Ozone blood therapy (autohemotherapy) is the process of withdrawing blood from the body using an IV catheter, enriching it with an oxygen/ozone mixture, then cycling that ozonated blood back into your bloodstream via the same catheter used for withdrawal.

❖ Medical ozone has the potential to help your body use oxygen to the fullest extent. Hyperbaric oxygen chambers are a different delivery method of the same concept; increasing the available oxygen in the body, so the immune system can function at the highest level.

❖ Systemic ozone blood therapy has been known to benefit the entire body. Instead of just alleviating symptoms, ozone autohemotherapy treats the root of disease.

❖ The oxygen we need to survive is made of two oxygen atoms (O2). Ozone is made of three oxygen atoms (O3). When medical ozone interacts with different fluids in your body (like blood), that third oxygen atom hitches a ride on the other molecules and results in higher levels of oxygenation.

❖ Oxygen is the thing humans need more than anything else. You can go days without eating, hours without drinking, but only minutes without breathing. The more oxygen your body has, the better it will function.

❖ Since inhaling ozone can be very irritating to the lungs, IV therapy is one of the safest ways to introduce much needed levels of oxygen into the body.

❖ Ozone therapy interacts with your body (but not your lungs) to optimize your body’s natural functions and help you operate at your highest level.

❖ Correctly administered ozone therapy can:

➢ Increase oxygen efficiency	➢ Decrease inflammation
➢ Balance the immune system	➢ Decrease pain
➢ Improve blood circulation	➢ Increase energy and sense of wellbeing

❖ Ozonated blood delivers oxygen-rich nutrients to every part of your body so that your body can function as it was designed to function.

❖ There are no adverse side effects associated with ozone IV therapy except for side effects associated with IV infusion since ozone/oxygen is not a medication.

❖ Ozone IV therapy is enjoyed by biohackers, people disenchanted with conventional medicine and even some professional athletes. Ozone therapy is used in European countries for many medical conditions. Ozone therapy has been extensively studied in Europe and Cuba for the last 60 years. Millions of treatments have been performed with a higher safety record than aspirin.

❖ Ozone therapy is potentially effective for treating viruses affecting the respiratory system, based on its proven effectiveness against other viral infections. As a complementary treatment, it is used with all standard protocols for the viral infection but it is not accepted by the US FDA.

❖ Multiple countries are using ozone therapy against respiratory viruses with reported success, including China, Italy, Spain and the United States. Italy has produced the most research with a reported 16 hospitals utilizing ozone therapy against respiratory viruses.

❖ One organization in Italy published a report of 46 respiratory viruses confirmed cases treated with ozone therapy. Out of the 46 patients, 39 significantly improved. This was the second report published, confirming the results of the first study.

❖ Some people claim that ozone is a miracle cure; the box of magic beans that will cure cancer and heal every disease. That is not true.

❖ Here’s how ozone actually actually works. Ozone stimulates and enhances your body’s natural defense mechanisms.

❖ Drugs and medications, while often necessary, don’t always address the root cause of the issue; your body’s ability to function at its highest level.

❖ While it doesn’t actually cure the cancer or the disease, correctly administered ozone has the potential to accomplish what most conventional medicine can’t.

❖ That’s because ozone is a biological response modifier which means it enhances the way your cells work. According to the International Scientific Committee of Ozone Therapy, ozone therapy can Increase oxygen efficiency, balance the immune system, improve blood circulation, decrease inflammation, decrease pain, and increase energy and sense of wellbeing.

❖ There are more than 40,000 doctors who treat diseases with ozone therapy on a daily basis in over 100 countries. This has given rise to a great deal of scientific research.

❖ Dr. Velio Bocci, a leading scientist, states that diseases treated with ozone therapy well when he writes: “We have good reasons to believe that the therapeutic power of ozone therapy consists of simultaneously improving circulation and oxygen delivery, in enhancing the release of autacoids, growth factors and cytokines and in reducing the endogenous, chronic oxidative stress. In other words, ozone therapy seems to act as a biological response modifier…ozone triggers a series of biological mechanisms that lead to normalizing the delivery of oxygen for several days with consequent therapeutic effects.”

❖ Ozone is said to cause “homeostasis” or a balanced state of the body. When ozone is administered, it creates a small amount of stress in the body. This is the same type of stress that is activated when you fast or exercise, so it produces the same, net result. The body recognizes the small, controlled amount of stress from ozone therapy and responds by balancing itself.

❖ Diseases positively impacted by a well-working immune system include:

➢ Cancer	➢ Macular degeneration (age related)	➢ Fibromyalgia
➢ Autoimmune diseases	➢ MRSA	➢ Parasitic infections
➢ Acute and chronic infections	➢ Acute and chronic ulcers	➢ Slipped disc
➢ Lyme disease	➢ Candidiasis	➢ Chronic fatigue syndrome
➢ Mold toxicity	➢ HIV	➢ Many people successfully heal from infection after a few rounds of ozone blood therapy in an integrative clinic
➢ Parasitic infections	➢ Dentistry

REFERENCES

WHAT IS NAD+?

WHAT IS OZONE IV THERAPY?

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